Journals
1. T. Larsen, S. Keller, S. Schmid, S. Dohn, A. Boisen, ”Fabrication and Characterization of SRN/SU-8 bimorph cantilevers for temperature sensing”, Microelectronic Engineering 88 (2010) 0167-9317
2. C. Jiang, L. Ouattara, C. Ingrosso, M. L. Curri, V. Krozer, A. Boisen, M. H. Jakobsen, and T. K. Johansen, “Microwave absorption properties of gold nanoparticle doped polymers”, Solid State Electronics 57(1) (2011) 19-22
3. A. Boisen, S. Dohn, S.S. Keller, S. Schmid and M. Tenje, “Cantilever-like micromechanical sensors”, Rep. Prog. Phys. 74 (2011) 036101
4. Fischer, L.M., et al., Development of a microfabricated electrochemical-cantilever hybrid platform. Sensors and Actuators B-Chemical, 2011. 157(1): p. 321-327.
5. X. Quan, L.M. Fischer, A. Boisen, M. Tenje, "Development of nanoporous gold electrodes for electrochemical applications", Microelectronic Engineering 88 (2011) 2379-2382
6. J. Nagstrup, S. Keller, K. Almdal, A. Boisen, "3D microstructuring of biodegradable polymers", Microelectronic Engineering 88 (2011) 2342-2344
7. M.F.Khan, S. Schmid, Z.J. Davis, S. Dohn and A. Boisen “Fabrication of resonant micro cantilevers with integrated transparent fluidic channel” Microelectronic Engineering 88 (2011) 2300-2303
8. T. Larsen, S. Schmid, L. Grönberg, A. O. Niskanen, J. Hassel, S. Dohn, A. Boisen, ”Ultra Sensitive String-Based Temperature Sensors”, Applied Physics Letters 98(12)1 (2011) 121901
9. S.S. Keller, N. Feidenhans’l, N. Fisker-Bødker, D. Soulat, A. Greve, D. Plackett, A. Boisen “Fabrication of biopolymer cantilevers using Nanoimprint lithography”, Microelectronic Engineering 88 (2011) 2294-2296
10. S.S. Keller, L. Gammelgaard, M.P. Jensen, S. Schmid, Z.J. Davis, A. Boisen “Deposition of biopolymer films on micromechanical sensors”, Microelectronic Engineering 88 (2011) 2311-2313
11. Keller, S.S., et al., Fabrication of biopolymer cantilevers using nanoimprint lithography. Microelectronic Engineering, 2011. 88(8): p. 2294-2296
12. L.H. Nielsen, S.S. Keller, K.C. Gordon, A. Boisen, T. Rades, A. Müllertz, “Spatial confinement can lead to increased stability of amorphous indomethacin”, Eur J Pharm Biopharm. 81(2) (2012) 418-25
13. A. Evgrafov, K. Marhadi “Control in the coefficients with variational crimes: Application to topology optimization of Kirchhoff plates,” Computer Methods in Applied Mechanics and Engineering 237-240, (2012) 27-38
14. Ping Li, Hanne Mørck Nielsen, Anette Müllertz, “Oral Delivery of Peptides and Proteins using Lipid-based Drug Delivery Systems”, Expert Opin. Drug Del. 9 (2012) 1289-1304
15. X. Quan, A. Heiskanen, Y. Sun, A. Labuda, A. Wolff, J. Dulanto, P. Grutter, M. Tenje, A. Boisen, “Development of Electrochemical Cantilever Sensors for DNA Applications", ECS Transactions - "Chemical Sensors 10" 50 (2013) 2077-81
16. M.F. Khan, S. Schmid, P.E. Larsen, Z.J. Davis, W. Yan, E.H. Stenby , A. Boisen, “Online characterization mass density and viscosity of pL fluid samples with suspended microchannel resonator” Sensors and Actuators B 185 (2013) 456– 461
17. L. Hagner Nielsen, T. Rades, A. Müllertz “Characterisation during storage and dissolution of solid dispersions containing furosemide and hydroxypropyl methylcellulose”, J. Drug Del. Sci. Tech. 23(4) (2013)
18. P. Marizza, S. S. Keller, A. Boisen, “Inkjet printing as a technique for filling of micro-wells with biocompatible polymers”, Microelectronic Engineering 111 (2013) 391-395
19. S.S. Keller, F.G. Bosco, A. Boisen ”Ferromagnetic shadow mask for spray coating of polymer patterns”, Microelectronic Engineering 110 (2013) 427-431
20. Ping Li, Hanne Mørck Nielsen, Mathias Fanø, Anette Müllertz, “Preparation and characterization of insulin-surfactant complexes for loading into lipid-based formulation”, J. Pharm. Sci. 8 (2013) 2689-2698
21. S. Bose, S.S. Keller, T.S. Alstrøm, A. Boisen, K. Almdal, “Process Optimization of Ultrasonic Spray Coating of Polymer Films”, Langmuir 29 (2013) 6911–6919
22. L. Hagner Nielsen, S. Sylvest Keller, A. Boisen, A. Müllertz, T. Rades. “Slow cooling rate of amorphous indomethacin increases the physical stability without influencing biorelevant dissolution behaviour”. Drug Delivery and Translational Research (2014), 4(3). p 268-274
23. Schmid, Silvan; Kurek, Maksymilian; Adolphsen, Jens Q, Anja Boisen; “Real-time single airborne nanoparticle detection with nanomechanical resonant filter-fiber” SCIENTIFIC REPORTS Volume: 3 Article Number: 1288 DOI: 10.1038/srep01288 (2013)
24. T. Larsen, S. Schmid, L.G. Villanueva, A. Boisen, ”Photothermal analysis of individual nanoparticulate samples using micromechanical resonators”, ACS Nano 7(7) (2013) 6188-6193
25. T. Larsen S. Schmid and A. Boisen “Micro String Resonators as Temperature Sensors”, Temperature: Its Measurement and Control in Science and Industry, Vol 8, 2013. 1552: p. 931-936.
26. L. Hagner Nielsen, S. Gordon, R. Holm, A. Selen, T. Rades, A. Müllertz “Preparation of an amorphous sodium furosemide salt improves solubility and dissolution rate and leads to a faster Tmax after oral dosing to rats”. Eur J Pharm Biopharm., 2013. 85(3): p. 942-951.
27. L. Hagner Nielsen, S. Gordon, J. Pekka Pajander, J. Ostergaard, T. Rades, A. Müllertz “Biorelevant characterisation of amorphous furosemide salt indicates conversion to a furosemide hydrate during dissolution”. Int. J. of Pharm., 2013. 457 (1): p: 14-24
28. Yamada, S., Schmid, S., Larsen, T., Hansen, O. and Boisen, A., Photothermal Infrared Spectroscopy of Airborne Samples with Mechanical String Resonators. Analytical Chemistry, 2013. 85(21): p. 10531-10535.
29. Li, Ping; Nielsen, Hanne Mørck; Fano, Mathias; Müllertz, Anette. Preparation and characterization of insulin-surfactant complexes for loading into lipid-based drug delivery systems.In: Journal of Pharmaceutical Sciences, Vol. 102, No. 8, 08.2013, p. 2689-98.
30. P. Marizza, S. S. Keller, A. Müllertz, I. Kikic , M. Moneghini, N. De Zordi , D. Solinas, A. Boisen, Polymer-filled microcontainers for oral delivery loaded using supercritical impregnation. Journal of Controlled Release, 2014. 173: p. 1-9.
31. M. F. Khan, S. Kim, D. Lee, S. Schmid, A. Boisen, T. Thundat, Nanomechanical identification of liquid reagents in a microfluidic channel. Lab on a Chip, 2014. 14(7): p. 1302-1307.
32. X.Quan,A. Heiskanen, M. Tenje and A. Boisen, In-situ monitoring of potential enhanced DNA related processes using electrochemical quartz crystal microbalance with dissipation (EQCM-D), Electrochemistry Communications 48 (2014) 111–114
33. Sanjukta Bose, Silvan Schmid, Tom Larsen, Stephan S. Keller, Anja Boisen and Kristoffer Almdal.., Micromechanical String Resonators: Analytical Tool for Thermal Characterization of Polymers. ACS Macro Letters, 2014. 3(1): p. 55-58.
34. Olga Mednova, Dorota Kwasny, Noemi Rozlosnik, Winnie Edith Svendsen, Kristoffer Almdal: New approach of long-term modification of Topas to acquire surface hydrophilicity for chromosome spreading. Applied surface Science, 292, 1045-1051 (2014)/doi: 10.1016/j.apsusc.2013.12.118
35. Dorota Kwasny, Olga Mednova, Indumathi Vedarethinam, Maria Dimaki, Asli Silahtaroglu, Zeynep Tümer, Kristoffer Almdal, Winnie E. Svendsen: All-polymer semi-closed device for metaphase chromosome spreading. Micromachines, 5, 158-170 (2014)/doi:10.3390/5020158
36. Grohganz H, Priemel PA, Löbmann K, Hagner Nielsen L, Laitinen R, Mullertz A, Van den Mooter G and Rades T. Refining stability and dissolution rate of amorphous drug formulations. Expert opinion on drug delivery (2014), 11 (6): p: 977-989
Journals – submitted/in preparation
37. C. Jiang, T. Larsen, T. K. Johansen and A. Boisen, “Microwave Readout Method for Cantilever-Based Sensors”, (Manuscript in preparation, Targeted Journal: Journal of MEMS)
38. Ping Li, Hanne Mørck Nielsen, and Anette Müllertz. Impact of emulsion-based drug delivery systems on insulin’s intestinal transport and uptake. (To be submitted soon).
39. Ping Li, Angel Tan, Clive Prestige, Hanne Mørck Nielsen, Anette Müllertz. Hypoglycemic activity and oral bioavailability of insulin-loaded SNEDDS (self-nanoemulsifying drug delivery systems), the effect of enteric coating and the drug loading in SNEDDS. (In preparation)
40. Ping Li, Angel Tan, Clive Prestige, Hanne Mørck Nielsen, Anette Müllertz. Hypoglycemic activity and oral bioavailability of insulin-loaded SNEDDS (self-nanoemulsifying drug delivery systems), the effect of silica and chitosan coating. (In preparation)
41. L. Hagner Nielsen, J. Nagstrup, S. Sylvest Keller, S. Gordon, J. Østergaard, T. Rades, A. Müllertz, A. Boisen “Controlled release from biodegradable microwells for oral drug delivery, in preparation
42. K. Marhadi, A. Evgrafov and M.P. Sørensen, “Optimal Design of Nano-Mechanical Sensors Using a Hybrid Continuous-Discontinuous Galerkin Method”, in preparation, Structural and Multidisciplinary Optimization.
43. X. Quan et al, “Characterization of Electromechanical Behavior of an Electrochemical Cantilever System”. Manuscript in preparation for Analytical Chemistry, 2014.
44. K. Marhadi and F. Khan, “Analytical study and optimization of resonant micro cantilever with integrated fluidic channel”, in preparation.
45. J. Nagstrup, S.S. Keller, A. Boisen ”Multi-layered micropatch for oral drug delivery fabricated by spin coating and laser machining”, in preparation
46. S.S. Keller, L.H. Nielsen, A. Boisen ”Enteric coating of microcontainers for oral drug delivery”, in preparation
47. Bose, S., et al., Microcantilever Sensors for Fast Analysis of Enzymatic Degradation of Poly (D, L-lactide). Manuscript to be submitted to Biomacromolecules, 2014.
48. Bose, S., et al., Micromechanical Fast Quasi-Static Detection of - and -Relaxations with Nanograms of Polymer. Manuscript to be submitted to Analytical Chemistry, 2014.
49. Petersen, R.S., et al., Hot Embossing and Mechanical punching of Biodegradable Microcontainers for Oral Drug Delivery. Manuscript submitted to Microelectronic engineering, 2014.
50. Petersen, R.S., et al., Fabrication of Two-leveled Ni Stamp for Hot Embossing of Microcontainers for Oral Drug delivery. Manuscript submitted to Journal of Micromechanics and Microengineering, 2014.
51. Petersen, R.S., et al., Hot punching of Biopolymers to Fabricate Discrete Microcontainers for Oral Drug Delivery. Manuscript to be submitted 2014.
52. Hagner Nielsen L, Sylvest Keller S, Boisen A, Müllertz A, Jacobsen J. In vitro characterisation of microcontainers as an oral drug delivery system - drug release and intestinal drug permeability of amorphous furosemide sodium salt. Manuscript to be submitted to International Journal of Pharmaceutics, 2014.
53. Hagner Nielsen L, Rades T, Müllertz A.. Solid dispersion of furosemide and polyvinylpyrrolidone increases the oral drug bioavailability in rats. In preparation
Conference Proceedings
1. S.S. Keller, L. Gammelgaard, M.P. Jensen, S. Schmid, Z.J. Davis, A. Boisen “Micromechanical sensors for the measurement of biopolymer degradation” Proceedings IEEE MEMS (2011)
2. X. Quan, L.M. Fischer, A. Boisen, M. Tenje, “Investigation of Electrochemical and Mechanical Behaviour of Electrochemical Cantilever Sensor by Electrochemical methods”, Proceedings ICNFA (2011)
3. X. Quan, L.M. Fischer, A. Boisen, M. Tenje, “Development and characterization of electrochemical cantilever sensor for bio/chemical sensing applications”, Proceedings MicroTAS (2011)
4. X. Quan, Y. Sun, A. Heiskanen, A. Wolff, P. Grutter, A. Boisen, “Investigation of cleaning and regeneration methods for reliable construction of DNA cantilever biosensors”, Proceedings NMC (2012)
5. T. Larsen, S. Schmid, L. Grönberg, A. O. Niskanen, J. Hassel, A. Boisen, “Metallic Micro Strings as Temperature Sensors”, Proceedings NMC2011 (2011)
6. T. Larsen, S. Schmid, A. Boisen, “Micro String Temperature Sensors”, Proceedings NMC2012 (2012).
7. C. Jiang, T. K. Johansen, Sæver Þór Jónasson, Lei Yan, and Anja Boisen “Cantilever-based Microwave Biosensors: Analysis, Designs and Optimizations”, ACES 2011, Williamsburg, United States, March 2011
8. K. Marhadi, A. Evgrafov, M.P. Sørensen “Topology Optimization of Nano-Mechanical Cantilever Sensors Using a C0 Discontinuous Galerkin-Type Approach”, 9th World Congress on Structural and Multidisciplinary Optimization June 13 -17, 2011, Shizuoka, Japan
9. Sævar Þór Jónasson, Brian Sveistrup Jensen, and Tom K. Johansen, “Study of Split-Ring Resonators for use on a Pharmaceutical Drug Capsule for Microwave Activated Drug Release”, in Proc. European Microwave Conference, Amsterdam, The Netherlands, Nov. 2012
10. Sævar Þór Jónasson, Vitaliy Zhurbenko and Tom K. Johansen, “Design and Characterization of a Low-Viscous Muscle Tissue Mimicking Media at the ISM-band (2.4-2.48 GHz) for Easy Antenna Displacement in In Vitro Measurements”, in Proc. Asia-Pacific Microwave Conference, Kaohsiung, Taiwan, Dec. 2012
11. J. Nagstrup, S.S. Keller, A. Müllertz, A. Boisen ”Micro containers with solid polymer drug matrix for oral drug delivery”, Proceedings MicroTAS (2012)
12. X.Quan, A. Heiskanen, P. Grutter, M. Tenje and A. Boisen. “Development of an electrochemical cantilever platform”, Proceeding NMC2014 (2014).
Conferences
1. J. Nagstrup, S. Keller, K. Almdal, A. Boisen, "3D microstructuring of biodegradable polymers", MNE '10 - 36th International Conference on Micro and Nano Engineering (Genoa, Italy, September 19-22 2010).
2. X. Quan, M. Tenje, L.M. Fischer, A. Boisen, "Development of nanoporous gold electrode for electrochemical methods applications", MNE '10 - 36th International Conference on Micro and Nano Engineering (Genoa, Italy, September 19-22 2010).
3. T. Larsen, S. Keller, S. Schmid, S. Dohn, A. Boisen, "Fabrication of SiNx-SU-8 hybrid cantilevers for temperature sensing", MNE '10 - 36th International Conference on Micro and Nano Engineering (Genoa, Italy, September 19-22 2010).
4. M.F. Khan, S. Schmid, Z.J. Davis, S. Dohn, A. Boisen, "Fabrication of resonant micro cantilevers with transparent integrated fluidic channels", MNE '10 - 36th International Conference on Micro and Nano Engineering (Genoa, Italy, September 19-22 2010).
5. S. Keller, M.P. Jensen, L. Gammelgaard, S. Schmid, Z.J. Davis, A. Boisen, "Deposition of biopolymer films on micromechanical sensors", MNE '10 - 36th International Conference on Micro and Nano Engineering (Genoa, Italy, September 19-22 2010).
6. S. Keller, N. Feidenhans'l, N. Fisker-Bødker, D. Soulat, A. Greve, D. Plackett, A. Boisen, "Fabrication of biopolymer cantilevers using nanoimprint lithography", MNE '10 - 36th International Conference on Micro and Nano Engineering (Genoa, Italy, September 19-22 2010).
7. S. Keller, N. Noeth, A. Boisen “Autonomous valve actuated by biopolymer degradation”, NanoBio Zurich 2010 (Zurich, Switzerland, August 24-27 2010)
8. S.S. Keller, L. Gammelgaard, M.P. Jensen, S. Schmid, Z.J. Davis, A. Boisen “Micromechanical sensors for the measurement of biopolymer degradation” IEEE 24th International Conference on Micro Electro Mechanical Systems (MEMS) (Cancun, Mexico, January 23-27 2011)
9. S.S. Keller, A. Greve, S. Schmid, Z.J. Davis, A. Boisen “Biodegradable micromechanical sensors”, 8th International Nanomechanical Sensing Workshop (Dublin, May 2011)
10. S. S. Keller ”Integrated nanomechanical sensor platforms for measurements in liquid”, Nanomedicine 2011 (Shenzhen, China, November 3-5 2011)
11. N. Masuda, S.S. Keller, R. Malureanu, M.H. Jakobsen, “Gold particle doped polymer materials for micro- and nanofabrication”, Nanoplasmonic sensors and spectroscopy 2011 (Göteborg, Sweden, September 19-22 2011)
12. X. Quan, L.M. Fischer, A. Boisen, M. Tenje, “Investigation of Electrochemical and Mechanical Behaviour of Electrochemical Cantilever Sensor by Electrochemical methods”, ICNFA 2011, International Conference on Nanotechnology: Fundamentals and Applications ( Ottawa, Canada, 27-29 Jul 2011)
13. X. Quan, L.M. Fischer, A. Boisen, M. Tenje, “Development and characterization of electrochemical cantilever sensor for bio/chemical sensing applications”, 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences (Seattle, Washington, USA, 2-6 Oct 2011)
14. T. Larsen, S. Schmid, L. Grönberg, A. O. Niskanen, J. Hassel, A. Boisen, “Metallic Micro Strings as Temperature Sensors”, NMC2011: 8th International Workshop on Nanomechanical Sensing, (Dublin, Ireland, May 11-13 2011).
15. M. F. Khan, S. Schmid, Z. J. Davis, A. Boisen “Transparent hollow micro cantilevers based mass sensor” NMC2011: 8th International Workshop on Nanomechanical Sensing, (Dublin, Ireland, May 11-13 2011).
16. M. F. Khan, S. Schmid, Z. J. Davis,W.Yan, E.H. Stenby, A. Boisen “Hollow cantilever-based density sensors with embedded microfluidic channel” MNE 2011 37th International Conference on Micro and Nano Engineering (Berlin, Germany, September 19-23 2011).
17. L. Hagner Nielsen, S. Sylvest Keller, K.C. Gordon, A. Boisen, T. Rades, A. Müllertz, "Spatial confinement of amorphous indomethacin increases stability", FIP Pharmaceutical World Congress / American Association of Pharmaceutical Scientists. (Washington, USA, November 2011) (poster presentation)
18. L. Hagner Nielsen, S. Sylvest Keller, K.C. Gordon, A. Boisen, T. Rades, A. Müllertz, "Spatial confinement of amorphous indomethacin increases stability", Pharmaceutical Solid State Research Cluster. (Helsinki, Finland, September 2011) (oral presentation)
19. O.Mednova, Kr.Almdal “Nanostructure toughened SU-8 epoxy resin by poly(ethylethylene)-poly(2-vinylpyridine) diblock copolymer incorporation”, PAT’11 – Polymers for Advanced Technologies (Lodz, Poland, October 2-5, 2011)
20. O.Mednova, Q.Huang, O. Hassager, Kr. Almdal ”Experimental investigation of high molar mass impuriries in steady elongational viscosity samples”, POC’2012 – Pure and Applied chemistry conference on Polymers and Organic Chemistry (Doha, Qatar, January 6-9, 2012)
21. Q.Huang, O.Mednova, H.K.Rasmussen, A.L.Skov, Kr.Almdal, O.Hassager “Are entangled polymer melts different from solutions?”, ICR’12 – XVIth International Congress on Rheology (Joao Maia, Portugal, August 5-10, 2012)
22. L. Hagner Nielsen, T. Rades, A. Müllertz, "Dissolution rates of spray dried amorphous salts of furosemide and HPMC in biorelevant dissolution media obtained by µ-DISS profiler", (8th World Meeting on Pharmaceutics, biopharmaceutics and Pharmaceutical Technology, Istanbul, Turkey, March 2012) (poster presentation)
23. L. Hagner Nielsen, S. Sylvest Keller, K.C. Gordon, A. Boisen, T. Rades, A. Müllertz, "Investigation by Raman microscopy if spatial confinement of amorphous indomethacin can lead to increased stability" (8th World Meeting on Pharmaceutics, biopharmaceutics and Pharmaceutical Technology, Istanbul, Turkey, March 2012) (poster presentation)
24. L. Hagner Nielsen, S. Sylvest Keller, K.C. Gordon, A. Boisen, T. Rades, A. Müllertz, "Stability of amorphous drug formulations in micro containers", (Day of Research, University of Copenhagen, Denmark, January 2012) (oral presentation)
25. L. Hagner Nielsen, S. Gordon, T. Rades, A. Müllertz, "Amorphous furosemide salt exhibits higher solubility and dissolution rate compared to amorphous furosemide acid", (CRS Nordic Chapter, Drug Delivery and Targeting, Reykjavik, Iceland, June 2012) (poster presentation)
26. L. Hagner Nielsen, T. Rades, A. Müllertz, "Preparation of amorphous furosemide salt formulations by spray drying" (CRS Nordic Chapter, Drug Delivery and Targeting, Reykjavik, Iceland, June 2012) (poster presentation)
27. X. Quan, Y. Sun, A. Heiskanen, A. Wolff, P. Grutter, A. Boisen, “Investigation of cleaning and regeneration methods for reliable construction of DNA cantilever biosensors”, 9th International Nanomechanical Sensing Workshop (Mumbai, India, June 6-8, 2012). Poster.
28. T. Larsen, S. Schmid, A. Boisen, “Micro Strings as Temperature Sensors”, ITS9: 9th International Temperature Symposium, (Los Angeles, California, USA, March 19-23 2012). Oral.
29. T. Larsen, S. Schmid, A. Boisen, “Micro String Temperature Sensors”, NMC2012: 9th International Workshop on Nanomechanical Sensing, (Mumbai, India, June 6-8 2012). Oral.
30. S. Schmid, and A. Boisen, Micro string resonators for real-time portable nanoparticle sensors, presented at SENN2012 International Congress on Safety of Engineered Nanoparticles and Nanotechnologies, Helsinki 2012. Oral
31. P. Marizza, S. Sylvest Keller, T. Rades, A. Müllertz, A. Boisen, Inkjet printing as a novel drug loading technique of micro-containers” PSSRC 2012, 6th Annual Symposium on Pharmaceutical Solid State Research Cluster, ( Lisbon, Portugal August 26-28 2012) Oral
32. P. Marizza, S. Sylvest Keller, A. Boisen, “Inkjet printing as a technique for filling of micro-wells with bio-compatible polymer” MNE12, 38th International Conference on Micro and Nano Engineering (Toulouse, France, September 16-20 2012). Poster.
33. X. Quan, Y. Sun, A. Labuda, A. Heiskanen, A. Wolff, J. Jorge Dulanto, P. Grutter, and A. Boisen, “Development of Electrochemical Cantilever Sensors for DNA Applications”, PRiME2012: 222th ECS meeting (Honolulu, Hawaii, October 7-12 2012). Oral
34. O.Mednova, D.Kwasny, K.Almdal, W.E.Svendsen; Long-term modification of a polymer microfluidic device for easy chromosom spreading ESIC 2012, 26th Conference of the European Colloid and Interface Society, (2-7 September 2012, Malmo, Sweden)
35. S.S. Keller, F.G. Bosco, A. Boisen ”Ferromagnetic shadow mask for spray coating of polymer patterns”, MNE ’12 – 38th International Conference on Micro and Nano Engineering (Toulouse, France, September 16 – 20 2012), oral
36. J. Nagstrup, S.S. Keller, A. Müllertz, A. Boisen ”Micro containers with solid polymer drug matrix for oral drug delivery”, MNE ’12 – 38th International Conference on Micro and Nano Engineering (Toulouse, France, September 16 – 20 2012), oral
37. S. Bose, S.S. Keller, A. Boisen, K. Almdal ”Process optimization for spray coating of Poly(vinyl pyrrolidone)”, MNE ’12 – 38th International Conference on Micro and Nano Engineering (Toulouse, France, September 16 – 20 2012), poster
38. J. Nagstrup, S.S. Keller, T. Rades, A. Müllertz, A. Boisen ”Spin coated films for use in micro patch drug delivery system”, American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition (Chicago, USA, October 14-18 2012), poster
39. L. Hagner Nielsen, S. Sylvest Keller, Anja Boisen, T. Rades, A. Müllertz. “Physical stability and dissolution of spatially confined amorphous indomethacin - the effect of different heating and cooling rates”. American Association of Pharmaceutical Scientists Annual Meeting (Chicago, USA, October 2012) poster
40. Ping Li, Hanne Mørck Nielsen and Anette Müllertz, Impact of emulsion-based drug delivery systems on insulin’s intestinal transport, American Association of Pharmaceutical Scientists Annual Meeting (Chicago, USA, October 2012) poster
41. Ping Li, Hanne Mørck Nielsen, Mathias Fanø and Anette Müllertz, Preparation and characterization of surfactant-insulin complex for loading into lipid-based formulations, American Association of Pharmaceutical Scientists Annual Meeting (Chicago, USA, October 2012) poster
42. L. Hagner Nielsen, S. Gordon, T. Rades, A. Müllertz. Higher apparent solubility and faster dissolution rate of amorphous furosemide salt leads to faster Tmax after oral dosing in rats compared to amorphous and crystalline furosemide acid. Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists - Australasian Pharmaceutical Science Association, December 2012 (Poster presentation)
43. L. Hagner Nielsen, T. Rades, A. Müllertz. Addition of hydroxypropyl methylcellulose to furosemide increases physical stability of the amorphous form of furosemide. Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists - Australasian Pharmaceutical Science Association, December 2012 (Poster presentation)
44. L. Hagner Nielsen, S. Gordon, T. Rades, A. Müllertz. Amorphous furosemide salt exhibits higher dissolution rate and stability compared to amorphous furosemide acid. Globalization of Pharmaceutics Education Network biennial meeting, Melbourne, November 2012 (Oral presentation)
45. S. Gordon, L. Hagner Nielsen, K. Naelapää, J. Rantanen, J. Østergaard, A. Müllertz. Biorelevant characterisation of the dissolution behaviour of furosemide polymorphs by UV imaging and flow through Raman spectroscopy. Globalization of Pharmaceutics Education Network biennial meeting, Melbourne, November 2012 (poster presentation)
46. L. Hagner Nielsen, S. Gordon, T. Rades, A. Müllertz. Improved in vitro properties of furosemide through utilisation of the amorphous sodium salt. Drug Delivery Australia, Australian Chapter of the Controlled Release Society (CRS), Melbourne, November 2012 (oral presentation)
47. L. Hagner Nielsen, S. Sylvest Keller, A. Boisen, T. Rades, A. Müllertz. Various heating and cooling conditions influence the release of amorphous indomethacin from microcontainers. Drug Delivery Australia, Australian Chapter of the Controlled Release Society (CRS), Melbourne, November 2012 (poster presentation)
48. L. Hagner Nielsen, S. Gordon, T. Rades, A. Müllertz. Amorphous furosemide salt exhibits higher dissolution rate and stability compared to amorphous furosemide acid. Annual meeting of the American Association of Pharmaceutical Scientists (AAPS), Chicago, October 2012 (poster presentation)
49. L. Hagner Nielsen, S. Sylvest Keller, A. Boisen, T. Rades, A. Müllertz. Physical stability and dissolution of spatially confined amorphous indomethacin - the effect of different heating and cooling rates. Annual meeting of the American Association of Pharmaceutical Scientists (AAPS), Chicago, October 2012 (poster presentation)
50. L. Hagner Nielsen, T. Rades, A. Müllertz. Dissolution characteristics of amorphous furosemide salt. Dissolution Group Meeting, Copenhagen, September 2012 (Oral presentation)
51. L. Hagner Nielsen, S. Sylvest Keller, A. Boisen, A. Müllertz. Spray coating of microcontainers with eudragit using ferromagnetic shadow masks for controlled oral release of poorly water soluble drugs, Annual meeting of the American Association of Pharmaceutical Scientists (AAPS), San Antonio, November 2013 (poster presentation)
52. S. Gordon, L. Hagner Nielsen, J. Pekka Pajander, J. Østergaard, T. Rades, A. Müllertz. Biorelevant dissolution behavior of amorphous furosemide forms as determined by UV imaging and Raman spectroscopy. Annual meeting of the American Association of Pharmaceutical Scientists (AAPS), San Antonio, November 2013 (poster presentation)
53. L. Hagner Nielsen, J. Nagstrup, S. Sylvest Keller, S. Gordon, J. Østergaard, Thomas Rades, A. Müllertz, A. Boisen. Biodegradable microcontainers as an oral drug delivery system for poorly soluble drugs. Annual meeting of the American Association of Pharmaceutical Scientists (AAPS), San Antonio, November 2013 (poster presentation)
54. L. Hagner Nielsen, S. Gordon, J. Pekka Pajander, J. Østergaard, A. Müllertz, T. Rades. Biorelevant characterisation of amorphous furosemide salt indicates conversion to a furosemide hydrate during dissolution. Pharmaceutical Solid State Research Cluster, Lille, France, July 2013 (oral presentation)
55. L. Hagner Nielsen, J. Nagstrup, S. Sylvest Keller, S. Gordon, J. Østergaard, Thomas Rades, A. Müllertz, A. Boisen. Biodegradable microcontainers as an oral drug delivery system for poorly soluble drugs. 39th International Conference on Micro and Nano Engineering, London, United Kingdom, September 2013 (poster presentation)
56. P. Marizza, S. Sylvest Keller, T. Rades, A. Müllertz, A. Boisen, “Loading of microcontainers for oral delivery with supercritical CO2 -aided impregnation”. PSSRC 2013, 7th Annual Symposium on Pharmaceutical Solid State Research Cluster, ( Lille, France, July 4-7 2013) Oral Presentation
57. P. Marizza, S. S. Keller, T. Rades, A. Müllertz, I. Kikic, M. Moneghini, N. De Zordi, D. Solinas, A. Boisen ”Drug-polymer filled micro-containers for oral delivery loaded using supercritical CO2 aided-impregnation ”. CRS 2013, 40th Annual Meeting & Exposition of the Controlled Release Society (Honolulu, Hawaii (USA), 21-24 2013). Oral presentation
58. Ping Li, Hanne Mørck Nielsen, Anette Müllertz. Self-nanoemulsifying Drug Delivery Systems (SNEDDS) for Oral Delivery of Insulin. (CRS Nordic Chapter, Drug Delivery and Targeting, Reykjavik, Iceland, June 2012) (oral presentation)
59. Ping Li, Hanne Mørck Nielsen and Anette Müllertz. Impact of emulsion-based drug delivery systems on insulin’s intestinal transport and uptake. Drug research academy (DRA) summer school, Helsinge, August 2012: “Biologics, ethics and presentation skills”. Poster
60. Ping Li, Hanne Mørck Nielsen and Anette Müllertz. Biotect Interest Group Meeting, Munich, October 2012.
61. S.S. Keller, L.H. Nielsen, A. Müllertz, A. Boisen, ”Enteric coating of microcontainers for oral delivery of poorly water soluble drugs”, 40th Annual meeting of the Controlled Release Society, July 21-24 2013 (Honolulu, Hawaii, USA) (poster)
62. Petersen, R.S., et al., Hot punching of individual biopolymer microcontainers for oral drug delivery. 39th International Conference on Micro and Nano Engineering, 2013, London (oral presentation)
63. S. Bose, S.S. Keller, A. Boisen, K. Almdal ” Process Optimization for Spray Coating of Poly (D, L-Lactic Acid) Films”, 49th Nordic Polymer Days (NPD 2012, 29-31 May 2012 , Copenhagen, Denmark), Poster presentation
64. S. Bose, S. Schmid, T. Larsen, S. S. Keller, A. Boisen, K. Almdal “Micro String Resonator: A New Analytical Tool for Thermal Characterization of Polymers” 10th International Workshop on Nanomechanical Sensing (NMC 2013, 1-3 May 2013, San Francisco, USA ) Poster presentation
65. S. Bose, S. Schmid, T. Larsen, S. S. Keller, A. Boisen, K. Almdal ” Detection of Glass Transition of Polymer by Micro Resonator” European Polymer Federation (EPF 2013, 16-21 June 2013, Pisa, Italy) Oral presentation
66. S. Bose, S.S. Keller, A. Boisen, K. Almdal “Cantilever Sensors As Tool to Measure Degradation of Biopolymer Coatings” 11th International Workshop on Nanomechanical Sensing (NMC 2014, 30 April 2 May 2014, Madrid, Spain): Poster presentation
67. S. Bose, S.S. Keller, A. Boisen, K. Almdal “Microcantilever: Tool to Measure Degradation of Biopolymer Coatings” Fourth International Workshop on Analytical Miniaturization and NANOtechnologies (WAM Nano 2014, 23-24 June 2014, Copenhagen, Denmark): Poster presentation
68. X.Quan, A. Heiskanen, P. Grutter, M. Tenje and A. Boisen. “Development of an electrochemical cantilever platform”, 11th Nanomechanical Sensing Workshop, Madrid, Spain, 30 April-2 May, 2014 (Poster).
69. X. Quan, A. Heiskanen, M. Tenje and A. Boisen “Characterization of Electromechanical Behavior of an Electrochemical Cantilever System”, 15th International Conference on Electroanalysis, Malmö, Sweden, 11-15 June, 2014 (Poster).
70. Hagner Nielsen L, Nagstrup J, Keller SS, Gordon S, Østergaard J, Rades T, Müllertz A, Boisen A. Biodegradable microcontainers as an oral drug delivery system for poorly soluble drugs. Annual meeting of the American Association of Pharmaceutical Scientists (AAPS), San Antonio, November 2013 (poster).
71. Gordon S, Hagner Nielsen L, Pajander JP, Østergaard J, Rades T, Müllertz A. Biorelevant dissolution behavior of amorphous furosemide forms as determined by UV imaging and Raman spectroscopy. Annual meeting of the American Association of Pharmaceutical Scientists (AAPS), San Antonio, November 2013 (poster).
72. Hagner Nielsen L, Keller SS, Boisen A, Müllertz A. Spray coating of microcontainers with eudragit using ferromagnetic shadow masks for controlled oral release of poorly water soluble drugs. Annual meeting of the American Association of Pharmaceutical Scientists (AAPS), San Antonio, November 2013 (poster)
73. Hagner Nielsen L, Sylvest Keller S, Jacobsen J, Boisen A, Müllertz A. Microcontainers as an oral drug delivery system. 10th International Conference and Workshop on Biological Barriers, Saarbrücken, Germany, February 2014 (poster)
74. Hagner Nielsen L, Nagstrup J, Keller SS, Gordon S, Østergaard J, Rades T, Boisen A , Müllertz A. Microcontainers, an innovative oral drug delivery system for poorly soluble drugs. 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Lisbon, Portugal, March/April 2014 (oral)
75. Hagner Nielsen L, Sylvest Keller S, Singh R, Jacobsen J, Boisen A, Müllertz A. In vitro characterization of microcontainers as an oral drug delivery system. 41st Annual Meeting & Exposition of the Controlled Release Society, Chicago, USA, July 2014 (poster)
76. Hagner Nielsen L, Sylvest Keller S, Marizza P, Singh R, Jacobsen J, Rades T, Müllertz A, Boisen A. Microcontainers as an oral drug delivery system . Controlled Release Society – Nordic Chapter meeting, Helsinki, Finland, August 2014 (poster)
77. Hagner Nielsen L, Sylvest Keller S, Jacobsen J, Rades T, Müllertz A, Boisen A. Microcontainers as an oral drug delivery system . The Globalization of Pharmaceutics Education Network, Helsinki, Finland, August 2014 (poster)
Patents
1. Faheem Khan et al: Cantilever based IR spectrometer” DTU patent number:92941-12
2. Faheem Khan et al: Hollow micro string based calorimetry device" DTU patent number: DTU Pat: 92957-12
3. Sævar Þór Jónasson: Ingestible Capsule for Remote Controlled Release of a Substance. REF Nr.: 12187095.0
4. Tom Larsen et al: A nano-string based mechanical photothermal spectrometer , Patent: DTU Pat. 92896-12
5. Silvan Schmid et al, A string-based mass sensor, DTU patent number: 92600-11
6. Johan Nagstrup et al, Multilayered micropatches (DTU Ref.: 95416 | Zacco Ref.: P81300665EP00 )
7. Ritika Singh et al. Hot Embossing of individual polymer microstructures (DTU ref.: 95443 | Zacco ref.: P81302265EP00)
Newsletter
Hagner Nielsen L and Müllertz A. Quality by design (QbD) approach in development and understanding of amorphous furosemide. AAPS QbD and Product Performance Focus Group Newsletter (2013); October
Internal reports
1. Chenhui Jiang: Cantilever-based Microwave Biosensors: Analysis, Designs and Optimizations
2. Stephan Keller: Biopolymer microcontainer for oral drug delivery
3. Stephan Keller: Biopolymer container for oral drug deliver
Student projects
The activities in NAMEC has attracted a number of student projects (bachelor and master projects). These activities highly support the NAMEC activites and generate additional results.
1. MSc project Noriyuki Masuda, “New Nanoparticle Doped Polymer Materials for Micro- and Nanofabrication”
2. BSc project, L. Gammelgaard and M.P. Jensen, “Micromechanical sensors for the measurement of biopolymer degradation”
3. BSc project, N. Feidenhans'l and N. Fisker-Bødker, ” Fabrication of biopolymer cantilevers using nanoimprint lithography”
4. BsC project, Saro Ulver Hierwagen and Esben Kirk Mikkelsen "Drug-in-a-box, Microfabrication of drug containers".
5. Msc project Milad Sabah Sakran, “Mucoadhesive polymeric micro-containers for gastrointestinal drug delivery”
6. Paolo Marizzia: Master project in the University of Trieste (Italy) has been financed with the following name: “Study of the separate effects of temperature, pressure and time in the impregnation of polymer-filled microcontainers”.
Ph.D. thesis
1. Tom Larsen, Micro-Mechanical Temperature Sensors, DTU September 2012
2. M. Faheem Khan, Microchannel resonators to characterize liquid samples, DTU November 2012
3. Johan Nagstrup, Micro fabrication of biodegradable polymer drug delivery devices, DTU January 2013
4. Line Hagner Nielsen, Drug formulations for microcontainers, KU Farma April 2013
5. Sævar Þór Jónasson , Microwave Activation of Drug Release, DTU Electro, April 2013
6. Xueling Quan, Development of Mechanical Biosensor for Metabolomics, DTU Nanotech, August 2013
7. Ping Li, Application of self-nanoemulsifying drug delivery systems for oral delivery of peptides and proteins, using insulin as a model protein, KU Farma, December 2013
8. Paolo Marizza, Loading of micro-cantainers for oral drug delivery, DTU Nanotech, January 2014
9. Sanjukta Bose, Degradation and mechanical characterization of polymers for drug delivery, DTU Nanotech, September 2014